How PRP and PRF Can Be Used in the Field of Dentistry?
Dental therapies include blood derivatives including platelet-rich plasma and platelet-rich fibrin, which are autogenic sources of numerous growth factors essential for tissue regeneration and healing.
The increased interest in the two biomaterials in regenerative customised medicine is also influenced by this fact. Numerous applications for platelet-rich forms are made possible by their diversity. One of the core products of the Plasmolifting Technologies are PRP-tubes that are also now used in the field of dentistry.
Use of platelet-rich plasma particularly in personalized dentistry
PRP that has eight times as many thrombocytes as the initial blood can be made, depending on the preparation procedure. In comparison to single centrifugation, double centrifugation allows one to obtain a larger concentration of thrombocytes and leukocytes.
Pure PRP (P-PRP), which is platelet-rich plasma that solely contains thrombocytes, can be distinguished from platelet-rich plasma that also contains leukocytes (L-PRP). They can be utilised as fibrin gels or an injectable suspension.
Unlike L-PRF and I-PRF, P-PRP releases the majority of its growth factors early on and totally dissolves after three days. The majority of the growth factors released by L-PRP are also released within the first few hours after its inception.
Description of unadulterated platelet-rich plasma use in dentistry
Scientists have been studying PRP’s effectiveness against different bacteria for years. According to one study, P-PRP has an antimicrobial effect on microorganisms including:
- Streptococcus agalactiae
- Candida albicans
- Enterococcus faecalis
- Streptococcus oralis.
Activity against P. aeruginosa was not verified in this study. In the research investigation, the effectiveness of P-PRP against a variety of bacteria was evaluated, including
- K pneumoniae.
After evaluating the activity of platelet-poor plasma, PRF and platelet-depleted plasma, relative to P. A. actinomycetemcomitans and gingivalis, antibacterial activity was demonstrated for all of these types. The microorganisms described above exhibited the maximum PRP activity, according to observations.
Similar findings from research were released in 2019 in Vietnam. One of the primary bacteria that cause periodontitis, P. gingivalis, was used as a test subject for the antimicrobial activity of PRP. The primary distinction was that they employed 12.5% PRP as opposed to another researcher’s use of 50% PRP.
In Vietnam, PRP treatment significantly reduced bacterial counts and decreased P. gingivalis adhesion in samples from both healthy and periodontitis patients. Another researcher’s investigation showed that growth was stopped for up to 2 hours, but that the bacteria eventually resumed growing.
Although the preliminary research findings are encouraging, more study is required to fully understand the role that PRP and PRF play in personalised dentistry. Because PRF and PRP are natural materials, they are biocompatible and biodegradable.
Because of this, procuring them does not result in unnecessary waste. They don’t induce allergic reactions because of their biocompatibility. Because of this, platelet concentrates are particularly fascinating for a variety of medical applications, including dentistry.
These characteristics are currently the most desired ones since products with these characteristics would be accepted by any organism. PRP and PRF are consequently products that can be used to treat a variety of illnesses.